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. Author manuscript; available in PMC: 2013 Jun 10.
Published in final edited form as: Clin Sci (Lond). 2011 Nov;121(10):427–436. doi: 10.1042/CS20110153

Figure 2. Maternal antioxidant therapy attenuates conditioned fear in mice programmed by exaggerated fetal glucocorticoid exposure.

Figure 2

Mice trained to associate an auditory cue with an aversive stimulus were placed in a masked context for 3 min prior to a 3 min exposure to the conditioned cue. Fearful behaviour (freezing) was measured in adult male (A) and female (B) offspring of dams that received either saline (solid symbols) or CBX (open symbols) along with either water (squares) or the antioxidant tempol (circles) during pregnancy. n = 13 male saline, n = 10 male CBX, n = 6 male saline–tempol, n = 6 male CBX–tempol, n = 14 female saline, n = 5 female CBX, n = 5 female saline–tempol, n = 4 female CBX–tempol; †P < 0.01 tempol compared with no tempol.