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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 May 1;23(13):3910–3913. doi: 10.1016/j.bmcl.2013.04.062

Scheme 2.

Scheme 2

(a) P(OMe)3, benzene, reflux, 24h, 90%; (b) NaH, THF, 0 C, then benzaldehyde, 12h, 0 C to rt, 66%; (c) 6N HCl/HOAc, TFA, reflux, 48h then H2 (1 atm), Pd/C (5%), rt, 1h, 50%; (d) MeOH, phenethylamine, 72h, rt then H2 (1 atm), 5% Pd/C (5%), EtOAc, 1h, 50%.