Table 3.
Summary of the Main Categories Revealed From Pathways and Network Analysis of the Tibial Microarray Data
| Top Canonical Pathways | P Value | Ratio |
|---|---|---|
| Calcium signaling | 5.28E-09 | 22/210 (0.105) |
| [Includes Acta1, Atp2a1, Camk2a, Camk2b, Casq1, Casq2, Chrna1, Myh1, Myh2, Myh4, Myh7, Myl1, Myl2, Myl3, Ryr1, Tnnc1, Tnnc2, Tnni2, Tnnt1, Tnnt3, Tpm2, Trdn] | ||
| Activation of interferon regulatory factor by cytosolic pattern recognition receptors | 2.05E-06 | 10/72 (0.139) |
| Interferon signaling | 1.96E-05 | 7/36 (0.194) |
| Glycolysis/gluconeogenesis | 7.49E-05 | 10/130 (0.077) |
| Integrin-linked kinase signaling | 2.09E-04 | 15/192 (0.078) |
| Top Upstream Regulators | P Value of Overlap | Predicted Activation State |
|---|---|---|
| DMD | 4.41E-30 | Activated |
| TRIM24 | 4.03E-23 | Inhibited |
| IFNA2 | 1.72E-22 | Activated |
| IFNB1 (includes EG:15977) | 2.78E-22 | Activated |
| MEF2C | 3.05E-21 | Activated |
| Diseases and Disorders | P Value | Molecules, n |
|---|---|---|
| Skeletal and muscular disorders | 1.99E-20 to 1.61E-02 | 167 |
| Neurological disease | 8.12E-14 to 1.22E-02 | 98 |
| Hereditary disorder | 1.43E-11 to 1.61E-02 | 105 |
| Cardiovascular disease | 3.92E-09 to 1.27E-02 | 66 |
| Developmental disorder | 7.06E-09 to 1.61E-02 | 71 |
| Molecular and Cellular Functions | P Value | Molecules, n |
|---|---|---|
| Cellular assembly and organization | 1.62E-07 to 1.58E-02 | 58 |
| Cellular function and maintenance | 1.62E-07 to 1.37E-02 | 114 |
| Carbohydrate metabolism | 2.34E-07 to 1.58E-02 | 67 |
| Cell morphology | 9.05E-07 to 1.74E-02 | 81 |
| Cell death | 2.08E-06 to 1.61E-02 | 109 |
| Physiological Systems | P Value | Molecules, n |
|---|---|---|
| Organ morphology | 4.18E-32 to 1.74E-02 | 134 |
| Skeletal and muscular system development and function | 4.18E-32 to 1.74E-02 | 153 |
| Embryonic development | 2.62E-12 to 1.74E-02 | 88 |
| Organ development | 2.62E-12 to 1.74E-02 | 98 |
| Organismal development | 2.62E-12 to 1.74E-02 | 118 |