. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Arthritis Rheum. 2012 Nov;64(11):3649–3659. doi: 10.1002/art.34639

Table 2.

Raman spectroscopic biochemical parameters^§ of the tibiae (Mean ± SD)

	Day 0 (5 months old)		Day 42 post-treatment				Two-way ANOVA (p-value)
	WT	TNF-tg	WT		TNF-tg		Treatment Placebo vs GC	Genotype WT vs TNF-tg	Interaction
	WT	TNF-tg	Placebo	GC	Placebo	GC	Treatment Placebo vs GC	Genotype WT vs TNF-tg	Interaction
MTMR	1.02±0.08	0.85±0.22	1.00±0.08	0.87±0.07	0.87±0.17	0.72±0.04	0.02*	0.02*	0.88

CTPR	0.99±0.06	1.06±0.12	1.00±0.03	1.05±0.03	1.04±0.09	1.12±0.02	0.02*	0.06	0.67

1660 cm⁻¹/1690 cm⁻¹ Ratio	0.98±0.11	0.99±0.24	1.00±0.02	1.10±0.06	0.99±0.14	1.13±0.06	0.02*	0.85	0.64

^§

The Raman parameters have been normalized by the average value calculated among mice in the WT placebo-treated group. (Normalization values were 3.1, 0.3, and 1.7 for the MTMR, CTPR, and 1660 cm⁻¹/1690 cm⁻¹ intensity ratio, respectively).