Table 1.
Behavior Test Statistics
| Test | I.D. | Mean +/− S.E. | N | Comparison | df | t | p | Adjusted p |
|---|---|---|---|---|---|---|---|---|
| Open Field Maze | ||||||||
| Locomotion | WT | 615.16 +/− 34.88 | 24 | WT v. OEp62 | 34 | 0.202 | 0.421 | 0.421 |
| OEp62 | 600.45 +/− 76.59 | 12 | WT v. p62:P392L | 50 | 1.462 | 0.075 | 0.225 | |
| p62:P392L | 555.79 +/− 22.83 | 28 | OEp62 v. p62:P392L | 38 | 0.738 | 0.232 | 0.421 | |
| Thigmotaxis | ||||||||
| Outer Zone (%) | WT | 82.78 +/− 1.27 | 24 | WT v. OEp62 | 34 | 10.005 | 5.75E-12 | <0.0001 |
| OEp62 | 41.78 +/− 5.33 | 12 | WT v. p62:P392L | 50 | 6.673 | 9.76E-09 | <0.0001 | |
| p62:P392L | 57.46 +/− 3.34 | 28 | OEp62 v. p62:P392L | 38 | −2.59 | 0.007 | 0.007 | |
| Inner Zone (%) | WT | 17.22 +/− 1.27 | 24 | WT v. OEp62 | 34 | −9.933 | 6.93E-12 | <0.0001 |
| OEp62 | 58.22 +/− 5.35 | 12 | WT v. p62:P392L | 50 | −6.673 | 9.76E-09 | <0.0001 | |
| p62:P392L | 42.54 +/− 3.34 | 28 | OEp62 v. p62:P392L | 38 | 2.562 | 0.007 | 0.007 | |
|
| ||||||||
| Elevated Plus Maze | ||||||||
| Anxiety | WT | 0.52 +/− 0.046 | 20 | WT v. OEp62 | 32 | 2.079 | 0.023 | 0.058 |
| OEp62 | 0.34 +/− 0.078 | 12 | WT v. p62:P392L | 26 | 0.87 | 0.196 | 0.196 | |
| p62:P392L | 0.61 +/− 0.111 | 6 | OEp62 v. p62:P392L | 20 | −1.997 | 0.029 | 0.059 | |
|
| ||||||||
| Forced Swim Test | ||||||||
| Immobility Time (%) | WT | 26.79 +/− 3.72 | 17 | WT v. OEp62 | 24 | 0.543 | 0.296 | 0.386 |
| OEp62 | 29.92 +/− 4.45 | 13 | WT v. p62:P392L | 19 | 0.293 | 0.386 | 0.386 | |
| p62:P392L | 25 +/− 2.03 | 8 | OEp62 v. p62:P392L | 15 | 0.782 | 0.223 | 0.386 | |
| Swimming | WT | 17.11 +/− 2.73 | 8 | WT v. OEp62 | 18 | −3.101 | 0.003 | 0.007 |
| OEp62 | 35.09 +/− 2.25 | 12 | WT v. p62:P392L | 12 | −3.529 | 0.002 | 0.006 | |
| p62:P392L | 31.17 +/− 1.51 | 6 | OEp62 v. p62:P392L | 16 | 0.345 | 0.367 | 0.367 | |
| Climbing | WT | 36.11 +/− 5.96 | 8 | WT v. OEp62 | 18 | 4.17 | 0.0003 | 0.0009 |
| OEp62 | 15.27 +/− 3.14 | 12 | WT v. p62:P392L | 12 | 2.464 | 0.015 | 0.029 | |
| p62:P392L | 22.83 +/− 1.42 | 6 | OEp62 v. p62:P392L | 16 | −1.769 | 0.048 | 0.048 | |
|
| ||||||||
| Barnes Maze | ||||||||
| Acquisition Day 5 | WT | 31.51 +/− 9.15 | 8 | WT v. OEp62 | 11 | 1.458 | 0.086 | 0.173 |
| OEp62 | 13.71 +/− 4.18 | 5 | WT v. p62:P392L | 15 | 1.746 | 0.051 | 0.152 | |
| p62:P392L | 14.96 +/− 3.75 | 9 | OEp62 v. p62:P392L | 12 | −0.209 | 0.419 | 0.419 | |
| Probe Trial 1 (Short Term) | WT | 36.6 +/− 4.85 | 8 | WT v. OEp62 | 11 | 0.247 | 0.405 | 0.405 |
| OEp62 | 34.98 +/− 2.64 | 5 | WT v. p62:P392L | 15 | −0.926 | 0.185 | 0.369 | |
| p62:P392L | 42.64 +/− 4.37 | 9 | OEp62 v. p62:P392L | 12 | −1.219 | 0.123 | 0.369 | |
| Probe Trial 2 (Long Term) | WT | 22.86 +/− 1.98 | 7 | WT v. OEp62 | 10 | −3.676 | 0.002 | 0.006 |
| OEp62 | 41.46 +/− 5.54 | 5 | WT v. p62:P392L | 14 | 4.78 | 0.32 | 0.32 | |
| p62:P392L | 25.34 +/− 4.28 | 9 | OEp62 v. p62:P392L | 12 | 2.333 | 0.019 | 0.039 | |
Adjusted p = Step-up Bonferroni Adjustment for Multiple Comparisons