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Oxidation and ageing cause a conformational change in CD47 upon which TSP-1 can bind. Under normal conditions, CD47 on the erythrocyte inhibits phagocytosis by interaction with SIRPα on the phagocyte. After the conformational change in CD47, TSP-1 is able to bind upon which interaction between CD47 and SIRPα leads to phagocytosis.
