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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Curr Osteoporos Rep. 2013 Jun;11(2):72–82. doi: 10.1007/s11914-013-0143-6

Figure 1. MicroRNAs stimulate osteoblast and osteoclast differentiation through ‘double negative’ circuits.

Figure 1

Figure 1

MicroRNAs control osteoblastogenesis (A) and osteoclastogenesis (B) through regulatory circuits in which microRNA interactions with the 3′UTRs of target mRNAs suppress (‘first negative’) the translation of proteins that inhibit (‘second negative’) the differentiation of osteoblasts or osteoclasts. Panels A and B illustrate two proposed circuits for either bone forming or bone promoting cells. Multiple other molecular circuits are known (or otherwise likely to exist) that may cross-regulate the factors shown in the diagram.