Table 1.
RT (min)a |
m/z (ESI mode) |
Identity | Mass error (ppm) |
RT error (min) |
MRM (ionization mode)b |
Trendc | Metabolic pathway |
Sensitive to |
---|---|---|---|---|---|---|---|---|
0.6 | 251.065+ | 2’-Deoxyuridine + Na+ | 4 | 0.0 | 227→ 184 (−) | ↑ | Pyrimidne metabolism | Aging |
0.3 | 188.175+ | N1-Acetylspermidine + H+ | 3 | 0.0 | 188→ 100 (+) | ↑ | Polyamine metabolism | Aging |
1.0 | 265.081+ | Thymidine + Na+ | 5 | 0.0 | 241→ 151 (−) | ↑ | Pyrimidne metabolism | Prior exposure |
0.3 | 228.097− | 2’-Deoxycytidine– H+ | 3 | 0.0 | 228→ 112 (−) | ↑ | Pyrimidne metabolism | Prior exposure |
0.4 | 151.026− | Xanthine – H+ | 0 | 0.1 | 151→ 107 (−) | ↑ | Purine metabolism | Aging |
0.5 | 227.066− | 2’-Deoxyuridine – H+ | 5 | 0.1 | 227→ 184 (−) | ↑ | Pyrimidne metabolism | Aging |
1.0 | 241.082− | Thymidine – H+ | 4 | 0.0 | 241→ 151 (−) | ↑ | Pyrimidne metabolism | Prior exposure |
0.8 | 283.066− | Xanthosine – H+ | 8 | 0.1 | 285→ 153 (+) | ↑ | Purine metabolism | Aging |
All RT (retention time) in reverse-phase global analysis.
Characteristic fragmentation reactions monitored for quantitation via multiple reaction monitoring (MRM).
All trends indicate statistically significant and consistent change after quantitation and normalization with respect to creatinine clearance.