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. 2013 Jul 1;140(13):2697–2702. doi: 10.1242/dev.088393

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© 2013. Published by The Company of Biologists Ltd

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Fig. 1. — Tbx2 expression in mouse dental mesenchyme can be induced by Bmp4. (A-D) Immunohistochemistry of E12.5 to E16.5 coronal sections using an anti-Tbx2 antibody shows expression in wild-type (WT) dental mesenchyme of the upper and lower molars. (E,F) Tbx2 expression in E13.5 wild-type (E) and Msx1^-/- (F) molar tooth buds. (G,H) Bmp4-soaked bead implantation results in expression of Tbx2 both in wild-type explant (n=15/15) (G) and in Msx1^-/- explant (n=4/5) (H) dental mesenchyme. Arrows indicate the expression domain of Tbx2 at the lingual side. Scale bars: 0.1 mm.