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. Author manuscript; available in PMC: 2013 Jun 11.
Published in final edited form as: Annu Rev Biophys. 2013 Mar 11;42:443–468. doi: 10.1146/annurev-biophys-083012-130338

Figure 1.

Figure 1

Simplified view of the TLR/IL-1R (left) and TNFR (right) pathways leading to activation of NF-κB. Known interactions between proteins are indicated and discussed in detail in the text. Abbreviations: IL-1R, interleukin-1 receptor; NF-κB, nuclear factor κB; TLR, Toll-like receptor; TNFR, tumor necrosis factor receptor.