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. Author manuscript; available in PMC: 2013 Jun 11.
Published in final edited form as: Annu Rev Biophys. 2013 Mar 11;42:443–468. doi: 10.1146/annurev-biophys-083012-130338

Figure 5.

Figure 5

Structures of TRAFs. (a) Domain organizations. (b) Crystal structure of the dimeric RING and ZF domains (ZF1-3) of TRAF6. (c) Crystal structure of the dimeric RING and ZF domain (ZF1) of TRAF2. (d) Crystal structure of TRAF6 RING and ZF domain (ZF1) in complex with Ubc13. (e) Crystal structure of TRAF2 CC in complex with cIAP2 BIR1 domain. (f, g) Crystal structure of the TRAF domain of TRAF2 in complex with a peptide from the CD40 receptor in space-filling and ribbon diagrams, respectively. (h, i) Crystal structure of the TRAF domain of TRAF2 in complex with the NTD of TRADD in space-filling and ribbon diagrams, respectively. (j) An infinite aggregation model of full-length TRAF proteins by alternating dimerization and trimerization. Abbreviations: CC, coiled coil; NTD, N-terminal domain; TRAF, tumor necrosis factor (TNF) receptor–associated factor.