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. Author manuscript; available in PMC: 2013 Jun 11.
Published in final edited form as: Annu Rev Biophys. 2013 Mar 11;42:443–468. doi: 10.1146/annurev-biophys-083012-130338

Figure 6.

Figure 6

Structures of the Myddosome and other membrane-proximal interactions in the TLR/IL-1R pathway. (a) Domain organizations. (b) Crystal structure of the DD complex of the Myddosome in two orientations, showing a structure with 6 MyD88, 4 IRAK4, and 4 IRAK1 or IRAK2 molecules. (c) A structural model of the membrane-proximal events in TLR signaling. Abbreviations: DD, death domain; IL-1R, interleukin-1 receptor; IRAK, interleukin-1 receptor (IL-1R)-associated kinase; MyD88, myeloid differentiation primary-response gene 88; TLR, Toll-like receptor.