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. Author manuscript; available in PMC: 2013 Jun 11.
Published in final edited form as: Annu Rev Biophys. 2013 Mar 11;42:443–468. doi: 10.1146/annurev-biophys-083012-130338

Figure 7.

Figure 7

The TAK1 complex and deubiquitinases in downregulating NF-κB signaling. (a) Domain organizations of TAK1 complex components. (b) Crystal structure of TAK1 kinase domain in complex with an activating peptide from TAB1. (c) Crystal structure of TAB2 NZF in complex with Lys63-linked di-ubiquitin. (d) Domain organizations of deubiquitinases A20 and CYLD. (e) Crystal structure of the OTU domain of A20. (f) Crystal structure of the fourth ZF domain of A20 in complex with three ubiquitin molecules. (g) Crystal structure of the USP domain of CYLD. The B-box is a small zinc-binding domain similar to RING domains. Abbreviations: NZF, Npl4 zinc finger; OTU, ovarian tumor domain; USP, ubiquitin-specific protease; ZF, zinc finger.