. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Food Funct. 2013 Feb;4(2):200–212. doi: 10.1039/c2fo30199g

Table 1.

In vitro studies of genistein function in non-β-cell type models

Model	Genistein (µM)	Duration	Effect	Mechanism	Ref
293 embryonic human kidney	0.00010	24 h	Gene transactivation	ERα and ERβ activation	35
RAW 264.7 cell	0.010	120 h	Osteoclast formation inhibitor	ERα and ERβ activation
RAW 264.7 cell	>10	120 h	apoptosis
MCF-7 cell	0.0010	48 h	proliferation	ERα and ERβ activation
MCF-7 cell	1	48 h	proliferation inhibition
In vitro	0.0000015	n/a	Concentration to displace labeled-E2 from ERα	IC₅₀ to determine relative binding affinity (RBA) for ERs
In vitro	0.000014	n/a	Concentration to displace labeled-E2 from ERβ	IC₅₀ to determine RBA for ERs
In vitro	15–50	n/a	Inhibit lipid peroxidation		53
In vitro	200	7 h	Inhibit peroxy radical oxidation of LDL		54
	5	107 min	inhibit copper-mediated oxidation of LDL		54
In vitro	100	n/a	scavenge at least 20% of hydroxyl radicals, 30% of DPPH radicals and 22% superoxide anion radicals		55
In vitro	180		inhibition of peroxidation of deoxyribose by hydroxyl radicals	IC₅₀	55
In vitro	>13	n/a	Reduce LDL oxidation		140