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Inactivation of Stat3 in POMC neurons alters blood pressure responses to stress and leptin. (A) Acute mean arterial pressure (MAP) responses to air-jet stress. Each value represents the average blood pressure for 5 minutes (n=6 animals/group). (B) Change in mean blood pressure (MAP) during chronic leptin infusion (4 μg/kg/min, IP) for 7 days (n=6/group). * p<0.05, Stat3flox/flox/POMC-Cre mice vs. Stat3flox/flox sex-matched control mice.
