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. 2013 May 27;2013:172537. doi: 10.1155/2013/172537

Figure 1.

Figure 1

Cumulative changes in body weight (CCBW) in C57BL/6 mice treated with either standard diet (Chow), HFD (DIO), and (a) HFD in combination with P. balsamifera at 125 or 250 mg/kg, or (b) HFD in combination with salicortin. Area under the curve (AUC) of CCBW for (c) total 8-week treatment period, (d) first 4 weeks of treatment (F1), and (e) second 4 weeks of treatment (F2). As mentioned, C57BL/6 mice were administered either standard diet (Chow), HFD (DIO), and for the last 8 of the 16 weeks a HFD in combination with P. balsamifera at 125 or 250 mg/kg, or with Salicortin 12.5 mg/kg. All values are mean ± SEM. Fraction 1 (F1) consists in the AUC between week 0 and 4, and fraction 2 (F2) corresponds to the AUC between week 4 and 8 of administration of the plant extract. The number of animals for the crude plant extract protocol was CHOW (n = 12), DIO (n = 8), P. balsamifera 125 (n = 5), and P. balsamifera 250 (n = 7); and for the salicortin protocol: CHOW (n = 12), DIO (n = 7), salicortin (n = 9). †denotes DIO significantly different as compared to Chow (unpaired Student's t test; P < 0.05). *denotes significantly different as compared to respective DIO (one way ANOVA; P < 0.05). §denotes significantly different as compared to respective DIO (unpaired Student's t test; P < 0.05).