Table 2.

Classification of the differentially expressed proteins revealed in the knee synovial tissues among the normal and vehicle-treated and QFGJS-treated CIA rats.

Classification	Subclassification	Name of proteins	Functions	Spot no.
Binding	Antigen binding	IgG-2a Ig gamma-2A chain C region	Nucleotide sequence and antibody effector functions	1
	Cytoskeletal protein binding	Anxa2 isoform short of Annexin A2	Calcium-regulated membrane-binding protein	13
	Protein binding	Des desmin	Class-III intermediate filaments	10
		Ogn osteoglycin	Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2	21
		Actb actin, cytoplasmic 1	Involved in various types of cell motility	23
		Serum albumin	Regulation of the colloidal osmotic pressure of blood	24
Metabolic process	Metabolic process	Gsto1 glutathione S-transferase omega-1	Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities	29
		Gstp1 glutathione S-transferase P	Conjugation of reduced glutathione to hydrophobic electrophiles	3
		Pgam1 phosphoglycerate mutase 1	Catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase)	12
		Tpi1 triosephosphate isomerase	Belongs to the triosephosphate isomerase family	8
	Lipid metabolic process	Apoe apolipoprotein E	Mediates the binding, internalization, and catabolism of lipoprotein particles	30
	Lipoprotein metabolic process	Apolipoprotein C-III, isoform CRA_b	Inhibits lipoprotein and hepatic lipase and decreases the uptake of lymph chylomicrons	4
	One-carbon metabolic process	Ca 3 carbonic anhydrase 3	Involved in the metabolism of xenobiotics and of natural substrates	6
	Oxidation reduction	Aldh2 protein	Aldehyde dehydrogenase (NAD) activity, identical protein binding	31
		Aldh6a1 methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	Plays a role in valine and pyrimidine metabolism	5
		Gpx1 glutathione peroxidase 1	Protects the hemoglobin in erythrocytes	14
		Ivd isovaleryl-CoA dehydrogenase, mitochondrial	It is Oxidoreductase	15
		Idh3a isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	It is Oxidoreductase	18
		Ldhb L-lactate dehydrogenase B chain	Identical protein, NAD or NADH binding, and L-lactate dehydrogenase activity	22
		Mdh1 malate dehydrogenase, cytoplasmic	Oxidoreductase, NAD or NADH binding, and L-malate dehydrogenase activity	28
		RGD1565368 similar to glyceraldehyde-3-phosphate dehydrogenase	Catalytic activity	19
	Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process	Np purine nucleoside phosphorylase	Transferase, glycosyltransferase, purine-nucleoside phosphorylase activity	26
	Glycolysis	RGD1560402 similar to phosphoglycerate kinase 1 (Pgk1)	Phosphoglycerate kinase activity	11
Regulation of biological process	Actin filament capping	Capzb F-actin-capping protein subunit beta	Blocking the exchange of subunits	17
		Capza2 F-actin-capping protein subunit alpha-2	Blocking the exchange of subunits	27
	Signal transduction	Anxa1 Annexin A1	Promotes membrane fusion and is involved in exocytosis	32
Cellular process	Protein transport	Selenbp1 Selenium-binding protein 1	Involved in the sensing of reactive xenobiotics	20
	Intermediate filament-based process	Vim vimentin	Plays a role in the stability of the cytoplasmic architecture	2
	Transmembrane transport	Vdac2 Voltage-dependent anion-selective channel protein 2	Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules	7
Other	Catalytic activity	Ces3 carboxylesterase 3	Involved in the metabolism of xenobiotics and of natural substrates	9
	Acute inflammatory response	Crp C-reactive protein	Displays several functions associated with host defense	16
	Cellular component	S100a4 protein S100-A4	Interacts with PPFIBP1 in a calcium-dependent mode	25

Spot no. denotes the number shown in the first column of Table 1.

The differentially expressed protein spots observed among the normal rats, CIA rats, and QFGJS-treated CIA rats are classified into five classes. 6 proteins are related to binding, 17 proteins are related to metabolic process, 3 proteins are related to biological process, and 3 proteins are related to cellular process and 3 proteins belongs to other class.