Figure 1.

The inhibitory effect of FAE on tyrosinase activity in vitro (a) and melanin content in murine B16BL6 cells stimulated with 100 nM α-MSH (b). Cells were treated with KA (60 μg/mL) or arbutin (100 μg/mL) and FAE at different doses (1, 100, 500 μg/mL). In vitro tyrosinase activities were measured based on the absorbance at 475 nm, and melanin contents are depicted as a percentage (%) of control. Each value was expressed with the mean ± SD of three independent experiments.