Table 1. Baseline Characteristics by Hp Genotype and Case Status Among Women Aged 44 to 69 Years at Blood Draw From a Nested Case-Control Study of CHD Events in the NHS, 1990 to 2004.
| Cases | Controls | |||||||
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| Characteristic | Hp1-1 (n = 58) | Hp2-1 (n = 188) | Hp2-2 (n = 161) | P | Hp1-1 (n = 66) | Hp2-1 (n = 189) | Hp2-2 (n = 156) | p |
| Age*(yrs) | 62.1 ± 6.3 | 59.3 ± 6.4 | 59.4 ± 6.6 | 0.01 | 60.8 ± 5.9 | 59.5 ± 6.7 | 59.5 ± 6.5 | 0.33 |
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| Smoking status* | ||||||||
| Never | 27 (47) | 63 (34) | 54 (34) | 0.44 | 26 (39) | 66 (35) | 55 (35) | 0.83 |
| Past | 18 (31) | 74 (39) | 62 (38) | 21 (32) | 75 (40) | 62 (40) | ||
| Current | 13 (22) | 51 (27) | 45 (28) | 19 (29) | 48 (25) | 39 (25) | ||
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| BMI (kg/m2) | 26.1 (24.9-27.4) | 26.0 (25.3-26.7) | 26.1 (25.3-26.9) | 0.97 | 25.5 (24.5-26.5) | 24.7 (24.1-25.3) | 25.0 (24.4-25.6) | 0.39 |
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| Activity (MET h/wk) | 9.2 (6.3-13.5) | 7.4 (6.0-9.17) | 9.8 (7.8-12.3) | 0.20 | 10.7 (7.9-14.6) | 9.6 (8.03-11.6) | 11.9 (9.77-14.6) | 0.30 |
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| Alcohol (g/d) | 2.46 (1.58-3.82) | 4.88 (3.97-6.00) | 4.16 (3.31-5.24) | 0.02 | 4.83 (3.42-6.81) | 4.45 (3.59-5.51) | 5.10 (4.09-6.35) | 0.68 |
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| Parental MI <60 yrs of age | 9 (16) | 41 (22) | 32 (20) | 0.58 | 7 (11) | 22 (12) | 25 (16) | 0.39 |
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| History of hypercholesterolemia | 25 (43) | 96 (51) | 99 (61) | 0.03 | 22 (33) | 79 (42) | 63 (40) | 0.48 |
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| History of hypertension | 30 (52) | 94 (50) | 82 (51) | 0.97 | 18 (27) | 47 (25) | 46 (29) | 0.63 |
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| History of diabetes | 10 (17) | 24 (13) | 24 (15) | 0.66 | 4 (6) | 13 (7) | 7 (5) | 0.64 |
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| Oral diabetic drug use | 2 (3) | 13 (7) | 5 (3) | 0.01 | 0 (0) | 2 (1) | 2 (1) | 0.18 |
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| Cholesterol-lowering drug use | 1 (2) | 8 (4) | 13 (8) | 0.12 | 1 (2) | 4 (2) | 5 (3) | 0.70 |
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| Postmenopausal hormone use† | 17 (29) | 59 (31) | 50 (31) | 0.43 | 24 (36) | 60 (32) | 59 (38) | 0.83 |
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| CRP (mg/L) | 0.30 (0.22-0.41) | 0.24 (0.20-0.28) | 0.26 (0.21-0.31) | 0.36 | 0.19 (0.15-0.25) | 0.19 (0.16-0.22) | 0.16 (0.14-0.19) | 0.49 |
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| Triglycerides (mg/dl) | 129.5 (113.7-147.6) | 121.4 (112.9-130.5) | 123.1 (113.8-133.1) | 0.69 | 107.4 (95.7-120.5) | 105.4 (98.5-112.9) | 104.3 (96.7-112.4) | 0.92 |
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| HbA1c (%) | 5.96 (5.69-6.24) | 5.76 (5.61-5.91) | 5.76 (5.62-5.94) | 0.43 | 5.46 (5.33-5.59) | 5.53 (5.45-5.61) | 5.43 (5.34-5.51) | 0.23 |
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| HbA1c ≥6.5% | 10 (17) | 23 (40) | 25 (43) | 0.001 | 3 (22) | 9 (64) | 2 (14) | 0.01 |
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| Total cholesterol (mg/dl) | 228 ± 53 | 232 ± 37 | 237 ± 40 | 0.33 | 222 ± 35 | 227 ± 42 | 229 ± 40 | 0.54 |
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| HDL cholesterol (mg/dl) | 53 ± 14 | 52 ± 15 | 52 ± 15 | 0.89 | 60 ± 18 | 59 ± 16 | 60 ± 17 | 0.90 |
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| LDL cholesterol (mg/dl) | 139 ± 50 | 143 ± 33 | 147 ± 36 | 0.29 | 130 ± 32 | 136 ± 40 | 137 ± 35 | 0.42 |
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| Apolipoprotein B (mg/dl) | 111 ± 36 | 114 ± 34 | 116 ± 33 | 0.68 | 104 ± 33 | 103 ± 30 | 107 ± 30 | 0.45 |
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| Adiponectin (ng/ml) | 7,142 (6,325-8,064) | 7,125 (6,661-7,623) | 7,515 (6,986-8,083) | 0.54 | 8,355 (7,553-9,245) | 8,541 (8,045-9,066) | 8,649 (8,099-9,240) | 0.85 |
Values are n (%), mean ± SD, or geometric mean (95% confidence interval [CI]). Participant characteristics were compared between genotypes by using a general linear model for continuous variables and chi-square tests for categorical variables, unless there was a cell with n < 5, in which case the Fisher exact test was used. For skewed variables (physical activity, alcohol, high sensitivity C-reactive protein [CRP], body mass index [BMI], glycosylated hemoglobin [HbA1c], triglycerides, and adiponectin), p values from log-transformed analyses and geometric means with reverse-transformed 95% CIs are displayed.
Case-control matching variable (also matched for fasting status and date at blood draw).
In postmenopausal women only.
CHD = coronary heart disease; HDL = high-density lipoprotein; Hp = haptoglobin; LDL = low-density lipoprotein; NHS = Nurses' Health Study.