Table 2.
Hp1-1 + Hp2-1 | Hp2-2 | |||||
---|---|---|---|---|---|---|
|
|
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Characteristic | Ca/Co | RR | Ca/Co | RR | 95% CI | p for Interaction |
All participants | ||||||
Matching factors only | 246/255 | Ref. | 161/156 | 1.07 | 0.81-1.42 | — |
Multivariate adjusted* | 246/255 | Ref. | 161/156 | 1.02 | 0.76-1.36 | — |
| ||||||
Age at baseline | ||||||
<60 yrs | 100/112 | Ref. | 77/67 | 1.21 | 0.71-1.78 | 0.40 |
≥60 yrs | 146/143 | Ref. | 84/89 | 0.92 | 0.63-1.36 | |
| ||||||
Smoking | ||||||
Never | 90/92 | Ref. | 54/55 | 0.97 | 0.59-1.60 | 0.87 |
Past | 92/96 | Ref. | 62/62 | 0.97 | 0.59-1.57 | |
Current | 64/67 | Ref. | 45/39 | 1.18 | 0.67-2.10 | |
| ||||||
Diabetes† | ||||||
No | 205/236 | Ref. | 130/146 | 0.97 | 0.71-1.32 | 0.38 |
Yes | 41/19 | Ref. | 31/10 | 2.05 | 0.73-5.72 | |
| ||||||
HbA1c | ||||||
<6.5% | 213/243 | Ref. | 136/154 | 0.95 | 0.70-1.29 | 0.04 |
≥6.5% | 33/12 | Ref. | 25/2 | 10.12 | 1.08-94.97 | |
| ||||||
History of hypercholesterolemia | ||||||
No | 125/154 | Ref. | 62/93 | 0.80 | 0.52-1.21 | 0.12 |
Yes | 121/101 | Ref. | 99/63 | 1.32 | 0.86-2.03 | |
| ||||||
LDL concentrations | ||||||
Normal (<160 mg/dl) | 173/193 | Ref. | 110/117 | 0.96 | 0.68-1.37 | 0.57 |
High (≥160 mg/dl) | 73/62 | Ref. | 51/39 | 1.14 | 0.64-2.01 |
Adjusted model included age, BMI, smoking status, alcohol intake, diabetes, history of hypercholesterolemia, and history of hypertension, unless stratified by 1 of these variables.
For analysis of risk of CHD by diabetes status, cases were updated as having diabetes if they developed diabetes before their CHD event, and controls were updated as having diabetes if diagnosed with diabetes before their matched case had a CHD event.
CI = confidence interval; CVD = cardiovascular disease; Ref. = reference; RR = relative risk; other abbreviations as in Table 1.