Table 2.

Multivariate RR^* of CHD With 95% CIs for Hp Genotypes, Together and Stratified According to CVD Risk Factors, in a Nested Case-Control Study of CHD in Women Aged 44 to 69 Years at Blood Draw From the NHS, 1990 to 2004

	Hp1-1 + Hp2-1		Hp2-2
Characteristic	Ca/Co	RR	Ca/Co	RR	95% CI	p for Interaction
All participants
Matching factors only	246/255	Ref.	161/156	1.07	0.81-1.42	—
Multivariate adjusted*	246/255	Ref.	161/156	1.02	0.76-1.36	—
Age at baseline
<60 yrs	100/112	Ref.	77/67	1.21	0.71-1.78	0.40
≥60 yrs	146/143	Ref.	84/89	0.92	0.63-1.36
Smoking
Never	90/92	Ref.	54/55	0.97	0.59-1.60	0.87
Past	92/96	Ref.	62/62	0.97	0.59-1.57
Current	64/67	Ref.	45/39	1.18	0.67-2.10
Diabetes†
No	205/236	Ref.	130/146	0.97	0.71-1.32	0.38
Yes	41/19	Ref.	31/10	2.05	0.73-5.72
HbA1c
<6.5%	213/243	Ref.	136/154	0.95	0.70-1.29	0.04
≥6.5%	33/12	Ref.	25/2	10.12	1.08-94.97
History of hypercholesterolemia
No	125/154	Ref.	62/93	0.80	0.52-1.21	0.12
Yes	121/101	Ref.	99/63	1.32	0.86-2.03
LDL concentrations
Normal (<160 mg/dl)	173/193	Ref.	110/117	0.96	0.68-1.37	0.57
High (≥160 mg/dl)	73/62	Ref.	51/39	1.14	0.64-2.01

^*Adjusted model included age, BMI, smoking status, alcohol intake, diabetes, history of hypercholesterolemia, and history of hypertension, unless stratified by 1 of these variables.

^†For analysis of risk of CHD by diabetes status, cases were updated as having diabetes if they developed diabetes before their CHD event, and controls were updated as having diabetes if diagnosed with diabetes before their matched case had a CHD event.

CI = confidence interval; CVD = cardiovascular disease; Ref. = reference; RR = relative risk; other abbreviations as in Table 1.