Table 4. Multivariate RR* of CHD Event with 95% CIs for Hp Genotypes, Together and Stratified by CVD Risk Factors, in a Prospective Study of Diabetic Men and Women Aged 22 to 95 Years From the ICARE Study, 2005 to 2006.
Hp1-1 + Hp2-1 | Hp2-2 | |||||
---|---|---|---|---|---|---|
|
|
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Characteristic | Event/No Event | RR | Event/No Event | RR | 95% CI | p for Interaction |
All participants | ||||||
Unadjusted | 7/1405 | Ref. | 22/636 | 6.83 | 2.92-15.98 | — |
Multivariate adjusted | 7/1405 | Ref. | 22/636 | 6.76 | 2.88-15.87 | — |
| ||||||
Age at baseline | ||||||
<69 yrs | 2/716 | Ref. | 12/289 | 13.72 | 3.06-61.54 | 0.16 |
≥69 yrs | 5/689 | Ref. | 10/347 | 3.73 | 1.27-11.01 | |
| ||||||
Previous MI | ||||||
No | 5/1218 | Ref. | 15/547 | 6.39 | 2.30-17.74 | 0.89 |
Yes | 2/187 | Ref. | 7/89 | 8.23 | 1.68-40.46 | |
| ||||||
Smoking | ||||||
No | 5/1284 | Ref. | 17/557 | 7.64 | 2.81-20.75 | 0.57 |
Yes | 2/121 | Ref. | 5/79 | 4.50 | 0.80-25.30 | |
| ||||||
HbA1c | ||||||
<6.5% | 2/406 | Ref. | 4/184 | 4.30 | 0.77-24.01 | 0.61 |
≥6.5% | 5/999 | Ref. | 18/452 | 7.55 | 2.79-20.47 | |
| ||||||
Years with diabetes | ||||||
≤8 yrs | 5/791 | Ref. | 11/366 | 4.59 | 1.58-13.29 | 0.39 |
>8 yrs | 2/614 | Ref. | 17/270 | 12.74 | 2.71-58.75 | |
| ||||||
Metformin use | ||||||
No | 2/312 | Ref. | 13/134 | 15.84 | 3.54-70.83 | 0.16 |
Yes | 5/1093 | Ref. | 9/502 | 3.77 | 1.26-11.30 |