. Author manuscript; available in PMC: 2014 Feb 19.

Published in final edited form as: J Am Coll Cardiol. 2013 Jan 9;61(7):728–737. doi: 10.1016/j.jacc.2012.09.063

Table 4. Multivariate RR^* of CHD Event with 95% CIs for Hp Genotypes, Together and Stratified by CVD Risk Factors, in a Prospective Study of Diabetic Men and Women Aged 22 to 95 Years From the ICARE Study, 2005 to 2006.

	Hp1-1 + Hp2-1		Hp2-2

Characteristic	Event/No Event	RR	Event/No Event	RR	95% CI	p for Interaction
All participants
Unadjusted	7/1405	Ref.	22/636	6.83	2.92-15.98	—
Multivariate adjusted	7/1405	Ref.	22/636	6.76	2.88-15.87	—

Age at baseline
<69 yrs	2/716	Ref.	12/289	13.72	3.06-61.54	0.16
≥69 yrs	5/689	Ref.	10/347	3.73	1.27-11.01

Previous MI
No	5/1218	Ref.	15/547	6.39	2.30-17.74	0.89
Yes	2/187	Ref.	7/89	8.23	1.68-40.46

Smoking
No	5/1284	Ref.	17/557	7.64	2.81-20.75	0.57
Yes	2/121	Ref.	5/79	4.50	0.80-25.30

HbA_1c
<6.5%	2/406	Ref.	4/184	4.30	0.77-24.01	0.61
≥6.5%	5/999	Ref.	18/452	7.55	2.79-20.47

Years with diabetes
≤8 yrs	5/791	Ref.	11/366	4.59	1.58-13.29	0.39
>8 yrs	2/614	Ref.	17/270	12.74	2.71-58.75

Metformin use
No	2/312	Ref.	13/134	15.84	3.54-70.83	0.16
Yes	5/1093	Ref.	9/502	3.77	1.26-11.30

A proportional hazards model was used, adjusted for sex, age, smoking status, hypertension, previous MI, statin use, and metformin use, unless stratified by 1 of these variables.

Abbreviations as in Tables 1, 2, and 3.

Table 4. Multivariate RR* of CHD Event with 95% CIs for Hp Genotypes, Together and Stratified by CVD Risk Factors, in a Prospective Study of Diabetic Men and Women Aged 22 to 95 Years From the ICARE Study, 2005 to 2006.

Table 4. Multivariate RR^* of CHD Event with 95% CIs for Hp Genotypes, Together and Stratified by CVD Risk Factors, in a Prospective Study of Diabetic Men and Women Aged 22 to 95 Years From the ICARE Study, 2005 to 2006.