. Author manuscript; available in PMC: 2013 Jun 11.

Published in final edited form as: J Gastrointest Cancer. 2011 Jun;42(2):100–111. doi: 10.1007/s12029-011-9262-4

Table 1.

PcG proteins and their implication in the pathogenesis of pancreatic cancer.

PRC2: INITIATION COMPLEX

PROTEIN	DOMAIN	FUNCTION	ROLE IN PaCa
EZH1/EZH2	SET	Histone methyltransferase activity (HMT), establishes H3- K37me3 mark	Oncogene verexpression associated with increased proliferation and invasion with reduction in cell cycle regulators; decreased E- cadherin expression associated with migration and invasion
SUZ12	Zinc finger	Required forHMT activity of PRC2
EED	WD40 repeat	Stabilization of N-terminal histone tail; required for HMT activity of PRC2
RBBP4/RBBP7	Histone binding	Histone binding

PRC1: MAINTENANCE COMPLEX

PROTEIN	DOMAIN	FUNCTION	ROLE IN PaCa
CBX2/4/8	Chromodomain	H3-K27me3 binding
CBX7	Chromodomain	Nucleosome targeting	Low levels associated with poor differentiation; decreased E-cadherin expression associated with migration and invasion
PHC1/2/3	Zinc finger SPM
RING1A/1B and RNF2	RING finger	Ubiquitin ligase	Oncogenes; overexpression associated with poor differentiation and invasion.
BMI1 and MEL18	Zinc finger, RING-type	Protein-protein interactions	Oncogenes; overexpression associated with poor differentiation, increased proliferation, EMT, invasion and “stemness”