Table III.
Association of VDR FokI and BsmI polymorphisms and PC risk.
| Group
|
|||||
|---|---|---|---|---|---|
| Genotype | PC, n (%) | Control, n (%) | OR | 95% CI | P-value |
| FokIa | |||||
| FF (CC) | 22 (24.2) | 37 (46.3) | 1 | ||
| Ff (CT) | 46 (50.5) | 31 (38.7) | 2.496 | 1.243–5.011 | 0.009 |
| ff (TT) | 23 (25.3) | 12 (15.0) | 3.223 | 1.344–7.733 | 0.008 |
| Ff+ff | 69 | 43 | 2.699 | 1.408–5.173 | 0.002 |
| FF | 22 | 37 | |||
| FF+Ff | 68 | 43 | |||
| F | 90 (49.5) | 105 (65.6) | 1 | ||
| f | 92 (50.5) | 55 (34.4) | 1.952 | 1.261–3.021 | 0.003 |
| BsmIb | |||||
| BB (AA) | 23 (25.3) | 26 (32.5) | 1 | ||
| Bb (AG) | 40 (44.0) | 41 (51.2) | 1.103 | 0.542–2.244 | 0.787 |
| bb (GG) | 28 (30.7) | 13 (16.3) | 2.435 | 1.026–5.780 | 0.042 |
| Bb+bb | 68 | 54 | 1.424 | 0.732–2.768 | 0.297 |
| BB | 23 | 26 | |||
| Bb+bb | 68 | 54 | |||
| B | 86 (47.3) | 93 (58.1) | 1 | ||
| b | 96 (52.7) | 67 (41.9) | 0.645 | 0.421–0.990 | 0.045 |
VDR, vitamin D receptor; PC, pancreatic cancer; OR, odds ratio; CI, confidence interval.
a
Ptrend=0.009;
b
Ptrend=0.0082.