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. 2013 Mar 5;5(5):1579–1582. doi: 10.3892/ol.2013.1225

Figure 2.

Figure 2

(A) Fluorescence in situ hybridization (FISH) using probes for BCR (green) and ABL (red) revealed 5 copies of BCR-ABL on the ider(22) chromosome in this case. (B) Using a probe for all acrocentric short arms, the breakpoints of ider(22) were shown to be located in the short arms. (C) Using immunohistochemistry, the dicentric character of the ider(22)s was proven. The CENP-B antibody stains all centromeres apart from that of the Y-chromosome, while the CENP-C antibody stains only active centromeres. Thus, it was also proven that the two centromeres were active on the ider(22). #, chromosome; der, derivative chromosome; ider, isoderivative chromosome.