Figure 1.

Chest computed tomography (CT) findings of the patient in this study. (A) Chest CT findings prior to gefitinib treatment reveal a mass in the right middle lobe with ipsilateral pleural effusion and atelectasis. (B) Chest CT findings on day 21 following gefitinib treatment reveal shrinkage of the mass in the right middle lobe, improved atelectasis and complete disappearance of pleural effusion. (C) On day 38 following gefitinib treatment, chest CT findings reveal new bilateral diffuse ground-glass shadows in addition to the findings in B. (D) The condition of the patient rapidly improved when methylprednisolone (240 mg/day) was administered for three days. (E) Chest CT findings following 18 months of gefitinib treatment revealed a significant shrinkage of the mass in the right middle lobe, and disappearance of atelectasis and pleural effusion.