Table III.
Summary of reported actions of TCM in apoptosis through the mTOR pathway.
| TCM | Cancer | Effect | Pathway | Reference |
|---|---|---|---|---|
| Osthole | Breast cancer | Inhibits proliferation | AKT/mTOR; induces apoptosis | (34) |
| SYUNZ-16 | Hepatoma | Inhibits growth Apoptosis | PKB/AKT AKT/FOXO |
(35) |
| Casticin | Leukemia | Apoptosis | PI3K/AKT | (36) |
| AECM | Breast cancer | Apoptosis | AKT | (37) |
| Antroquinonol | Hepatoma | G1 arrest; apoptosis | AMPK mTOR |
(38) |
TCM, traditional Chinese medicine; AECM, aqueous extract of Cordyceps militaris; AKT, v-akt murine thymoma viral oncogene homolog 1; mTOR, mammalian target of rapamycin; PKB, protein kinase B; FOXO, forkhead box; PI3K, phosphoinositide-3-kinase.