. 2013 Jun 6;8:273–286. doi: 10.2147/COPD.S43992

Table A1.

Cox regression models: treatment failure

Variable	Univariate analysis			Multivariate analysis CCQ				Multivariate analysis SGRQ			Multivariate analysis BORG
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Treatment arm	0.980	(0.519–1.851)	0.950	1.086	(0.472–2.502)	0.846	1.228	(0.549–2.749)	0.616	1.159	(0.690–3.666)	0.276
FEV₁% predicted	0.967	(0.939–0.996)	0.024	0.949	(0.907–0.993)	0.024	0.971	(0.935–1.009)	0.129	0.636	(0.927–1.001)	0.590
Age	1.007	(0.969–1.047)	0.720	1.003	(0.952–1.056)	0.918	1.019	(0.963–1.078)	0.512	1.010	(0.956–1.068)	0.715
Male gender	1.026	(0.486–2.169)	0.945	1.239	(0.429–3.575)	0.692	1.094	(0.369–3.249)	0.871	0.763	(0.264–2.209)	0.618
Smoking status	0.831	(0.381–1.812)	0.641	0.632	(0.217–1.839)	0.400	0.534	(0.195–1.461)	0.222	0.513	(0.183–1.435)	0.203
Packyears	0.990	(0.974–1.007)	0.258
Previous admission	1.328	(0.878–2.009)	0.180
Previous admission > 2	2.283	(0.810–6.438)	0.119
O₂ use at home	2.923	(1.449–5.897)	0.003	0.952	(0.3 12–2.905)	0.932	1.821	(0.702–4.725)	0.218	2.430	(0.923–6.398)	0.072
BMI	0.986	(0.925–1.052)	0.671
BMI < 2I	0.872	(0.340–2.233)	0.775
O₂ sat	1.000	(0.969–1.032)	0.997
O₂ sat t1t2	0.957	(0.879–1.042)	0.307
pH	0.038	(0.001–1.323)	0.071
pH t1t2	0.000	(0.000–1.463)	0.059
Pa, O₂	0.939	(0.804–1.097)	0.429
Pa, O₂t1t2	0.837	(0.686–1.021)	0.079
Pa, CO₂	1.451	(1.123–1.874)	0.004	1.207	(0.855–1.705)	0.286	1.396	(0.998–1.953)	0.052	1.304	(0.933–1.822)	0.120
Pa, CO₂t1t2	1.003	(0.717–1.403)	0.986
HBCO	0.946	(0.711–1.260)	0.705
HbCO t1t2	1.153	(0.830–1.602)	0.395
Hypoxaemia	1.071	(0.477–2.405)	0.869
Hypercapnea	0.544	(0.165–1.793)	0.317
Acidotic	0.378	(0.145–0.988)	0.047
CRP	1.000	(0.996–1.004)	0.921
ESR	1.007	(0.995–1.018)	0.255
Glucose	0.988	(0.953–1.023)	0.493
SGRQ total score	0.978	(0.959–0.999)	0.037				0.979	(0.954–1.004)	0.098
SGRQ symptoms	0.989	(0.972–1.008)	0.250
SGRQ impact	0.980	(0.961–1.000)	0.045
SGRQ activity	0.987	(0.972–1.003)	0.100
CCQ total	0.217	(0.943–1.757)	0.294
CCQ symptoms	0.927	(0.678–1.267)	0.633
CCQ functional status	1.264	(0.942–1.695)	0.119
CCQ mental status	1.144	(0.932–1.402)	0.198
CCQ tt1t2	0.062	(0.072–0.929)	0.017
CCQ st1t2	0.624	(0.471–0.828)	0.001	0.636	(0.427–0.947)	0.026
CCQ ft1t2	0.783	(0.610–1.004)	0.054
CCQ mt1t2	1.077	(0.860–1.349)	0.518
CCQ st1t2 > 0	0.339	(0.171–0.671)	0.002
BORG	1.151	(0.989–1.340)	0.070
BORG t1t2	1.171	(0.997–1.375)	0.055							1.143	(0.924–1.415)	0.218
BORG t1t2 > 0	0.278	(0.038–2.029)	0.207

Abbreviations: BMI, body mass index; CI, confidence interval; CCQ, Clinical COPD Questionnaire; CSR, C-reactive protein; ESR, erythrocyte sedimentation rate; HR, hazard ratio; SGRQ, St George’s Respiratory Questionnaire; FEV₁ forced expiratory flow in one second.