Table A2.
Cox regression models: time to exacerbation
| Variable | Univariate analysis
|
Multivariate analysis CCQ
|
Multivariate analysis SGRQ
|
Multivariate analysis BORG
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Treatment arm | 1.243 | (0.857–1.804) | 0.252 | 1.170 | (0.793–1.727) | 0.428 | 1.056 | (0.673–1.657) | 0.812 | 1.179 | (0.783–1.177) | 0.431 |
| FEV1% predicted | 0.992 | (0.980–1.004) | 0.212 | 0.996 | (0.983–1.009) | 0.561 | 0.994 | (0.979–1.008) | 0.377 | 0.992 | (0.979–1.005) | 0.249 |
| Age | 1.018 | (0.996–1.042) | 0.114 | 1.016 | (0.989–1.042) | 0.245 | 1.007 | (0.977–1.038) | 0.646 | 1.015 | (0.988–1.044) | 0.278 |
| Male gender | 1.624 | (1.026–2.517) | 0.038 | 1.636 | (0.985–2.718) | 0.057 | 1.766 | (0.968–3.221) | 0.064 | 1.566 | (0.937–2.216) | 0.087 |
| Smoking status | 0.769 | (0.492–1.201) | 0.249 | 0.888 | (0.557–1.418) | 0.620 | 0.698 | (0.400–1.221) | 0.208 | 0.892 | (0.553–1.439) | 0.640 |
| Packyears | 1.004 | (0.995–1.013) | 0.384 | |||||||||
| Previous admission | 1.295 | (0.910–1.765) | 0.101 | |||||||||
| Previous admission > 2 | 1.305 | (0.573–2.972) | 0.527 | |||||||||
| O2 use at home | 1.373 | (0.753–2.503) | 0.301 | |||||||||
| BMI | 0.975 | (0.936–1.016) | 0.226 | |||||||||
| BMI < 2I | 1.137 | (0.649–1.199) | 0.654 | |||||||||
| SGRQ total score | 0.995 | (0.984–1.007) | 0.440 | 0.995 | (0.983–1.007) | 0.423 | ||||||
| SGRQ symptoms | 1.000 | (0.988–1.013) | 0.938 | |||||||||
| SGRQ impact | 0.995 | (0.985–1.006) | 0.358 | |||||||||
| SGRQ activity | 0.997 | (0.989–1.006) | 0.558 | |||||||||
| CCQ total | 1.233 | (1.047–1.452) | 0.012 | 1.213 | (1.007–1.462) | 0.042 | ||||||
| CCQ symptoms | 1.215 | (1.049–1.407) | 0.009 | 1.178** | (1.008–1.376) | 0.040 | ||||||
| CCQ functional status | 1.158 | (I.0I7–I.3I9) | 0.027 | |||||||||
| CCQ mental status | 1.041 | (0.907–1.194) | 0.570 | |||||||||
| BORG | 0.981 | (0.912–1.054) | 0.595 | 0.996 | (0.924–1.074) | 0.912 | ||||||
Note: **Using CCQ symptoms instead of total score.
Abbreviations: BMI, body mass index; CI, confidence interval; CCQ, Clinical COPD Questionnaire; HR, hazard ratio; SGRQ, St George’s Respiratory Questionnaire; FEV1 forced expiratory flow in one second.