Table A3.
Cox regression models: mortality
| Variable | Univariate analysis
|
Multivariate analysis CCQ
|
Multivariate analysis SGRQ
|
Multivariate analysis BORG
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Treatment arm | 1.042 | (0.673–1.612) | 0.855 | 1.079 | (0.689–1.691) | 0.740 | 0.987 | (0.597–1.632) | 0.959 | 1.015 | (0.642–1.606) | 0.949 |
| FEV1% predicted | 0.986 | (0.972–1.001) | 0.062 | 0.989 | (0.971–1.006) | 0.199 | 0.976 | (0.958–0.995) | 0.012 | 0.980 | (0.964–0.996) | 0.015 |
| Age | 1.046 | (1.016–1.076) | 0.002 | 1.083 | (1.046–1.121) | 0.000 | 1.080 | (1.037–1.125) | 0.000 | 1.088 | (1.048–1.130) | 0.000 |
| Male gender | 1.199 | (0.710–2.025) | 0.498 | 0.888 | (0.498–1.582) | 0.686 | 1.156 | (0.595–2.248) | 0.668 | 0.940 | (0.529–1.672) | 0.833 |
| Smoking status | 1.166 | (0.709–1.919) | 0.545 | 1.922 | (1.113–3.316) | 0.019 | 2.186 | (1.155–4.136) | 0.016 | 1.797 | (1.042–3.100) | 0.035 |
| Packyears | 1.001 | (0.991–1.011) | 0.870 | |||||||||
| Previous admission | 1.330 | (0.935–1.892) | 0.112 | |||||||||
| Previous admission > 2 | 1.755 | (0.763–4.036) | 0.186 | |||||||||
| O2 use at home | 1.787 | (0.945–3.382) | 0.074 | 1.537 | (0.702–3.361) | 0.282 | 1.798 | (0.431–4.422) | 0.201 | 1.976 | (0.881–4.436) | 0.099 |
| BMI | 0.965 | (0.918–1.015) | 0.168 | |||||||||
| BMI < 2I | 1.852 | (1.022–3.357) | 0.042 | 1.896 | (0.958–3.752) | 0.066 | 1.359 | (0.602–3.066) | 0.460 | 1.561 | (0.793–3.069) | 0.197 |
| SGRQ total score | 1.001 | (0.987–1.015) | 0.905 | 1.005 | (0.989–1.021) | 0.530 | ||||||
| SGRQ symptoms | 0.999 | (0.986–1.011) | 0.821 | |||||||||
| SGRQ impact | 1.003 | (0.991–1.015) | 0.586 | |||||||||
| SGRQ activity | 0.998 | (0.988–1.008) | 0.688 | |||||||||
| CCQ total | 1.410 | (1.176–1.69I) | 0.000 | 1.383 | (1.103–1.733) | 0.005 | ||||||
| CCQ symptoms | 1.242 | (1.048–1.472) | 0.012 | |||||||||
| CCQ functional status | 1.443 | (1.236–1.685) | 0.000 | 1.402** | (1.169–1.68I) | 0.000 | ||||||
| CCQ mental status | 1.027 | (0.874–1.207) | 0.746 | |||||||||
| BORG | 0.982 | (0.900–1.071) | 0.677 | 1.017 | (0.927–1.115) | 0.723 | ||||||
Note:
**
Using CCQ functional status instead of total score.
Abbreviations: BMI, body mass index; CI, confidence interval; CCQ, Clinical COPD Questionnaire; HR, hazard ratio; SGRQ, St George’s Respiratory Questionnaire; FEV1 forced expiratory flow in one second.