Table III.
Clinical characteristics of 49 patients with pharyngeal FDC sarcoma from literature (case 4–52).
| Case no. | Reference | Age (years) | Gender | Size (cm) | Sites | Initial diagnosis | Initial treatment | Recurrence, DFT (months) | Status | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | Chan et al(38), 1994 | 44 | M | 1.5 | Tonsil | FDC tumor | Surg | NA | NED | 36 |
| 5 | Chan et al(38), 1994 | 63 | F | 3×3×2 | Soft palate | Acinic cell carcinoma | Surg + RT | NA | NED | 54 |
| 6 | Perez-Ordonez et al(39), 1996 | 62 | F | NA | Tonsil | NA | Surg | NA | NED | 12 |
| 7 | Nayler et al(40), 1996 | 18 | F | 4×2×2 | Tonsil | FDC tumor | Surg + ChT | NA | NA | NA |
| 8 | Chan et al(5), 1997 | 32 | M | NA | Tonsil | NA | Surg + RT | LR & DM (LN), 54 | AWD | 54 |
| 9 | Chan et al(5), 1997 | 40 | F | 7×3×2 | Parapharyngeal space | NA | Surg | LR, 12 | AWD | 12 |
| 10 | Beham-Schmid et al(41), 1998 | 44 | M | 2 | Nasopharynx | FDC tumor | Surg + RT + ChT | NA | NED | 20 |
| 11 | Desai et al(20), 1999 | 45 | F | 6×3×3 | Parapharyngeal space | Ectopic meningioma | Surg | LR, 31 | NED | 57 |
| 12 | Araujo et al(25), 1999 | 14 | M | 1.5×1.0×0.5 | Palate | Fibrous histiocytoma | Surg | NA | NED | 5 |
| 13 | Chan et al(14), 2001 | 23 | M | 1 | Nasopharynx | No specific inflammation | Surg | NA | NED | 36 |
| 14 | Vargas et al(42), 2002 | 54 | F | 3 | Tonsil, CLN | FDC tumor | Surg | NA | NED | 8 |
| 15 | Vargas et al(42), 2002 | 54 | F | 6 | Parapharyngeal space, parotid | FDC tumor | Surg + RT | LR, 6 | AWD | 8 |
| 16 | Biddle et al(2), 2002 | 48 | M | 3.5×2×2 | Tonsil | FDC sarcoma | Surg | NA | NED | 8 |
| 17 | Biddle et al(2), 2002 | 48 | F | 1.5×1.2×1.0 | Tonsil, CLN | Low-grade malignancy | Surg | NA | NED | 6 |
| 18 | Biddle et al(2), 2002 | 33 | M | NA | Pharynx | Malignant schwannoma | Surg + RT | DM (lung), 10 | AWD | 10 |
| 19 | Tish et al(36), 2003 | 51 | M | NA | Tonsil | FDC sarcoma | Surg + RT | NA | NED | 60 |
| 20 | Satoh et al(26), 2003 | 16 | M | 3.0×2.5 | Parapharyngeal space, palate | Low-grade malignancy | Surg + RT + ChT | NA | NED | 24 |
| 21 | Wang et al(27), 2003 | 59 | M | 3 | Pharynx | NESCTWEF* | Surg | NA | NED | 48 |
| 22 | Dominguez-Malagon et al(9), 2004 | 29 | F | 4.8 | Parapharyngeal space | Malignant meningioma | Surg + RT | LR, 12 | STD | 132 |
| 23 | Dominguez-Malagon et al(9), 2004 | 48 | M | 1.5 | Tonsil, CLN | FDC sarcoma | Surg + RT | NA | NED | 36 |
| 24 | Dominguez Malagon et al(9), 2004 | 26 | M | NA | Parapharyngeal space | FDC sarcoma | Surg + RT + ChT | DM (lung), 36 | AWD | 72 |
| 25 | Idrees et al(28), 2004 | 77 | F | NA | Tonsil | SCC | Surg + RT | DM (LN, lung), 96 | AWD | 96 |
| 26 | Georglass et al(43), 2004 | 61 | M | 5×4 | Hypopharynx, CLN | FDC sarcoma | Surg | NA | NA | NA |
| 27 | Grogg et al(44), 2004 | 57 | F | NA | Tonsil, CLN, ALN | NA | Surveillance | NA | AWD | 8 |
| 28 | Bothra et al(29), 2005 | 45 | M | NA | Tonsil | UD-carcinoma | Surg | NA | NED | 12 |
| 29 | Bothra et al(29), 2005 | 45 | M | NA | Tonsil | UD-carcinoma | Surg | NA | NED | 12 |
| 30 | Bothra et al(29), 2005 | 34 | M | NA | Tonsil | FDC sarcoma | Surg | LR, 120 | AWD | 120 |
| 31 | Chou et al(45), 2005 | 61 | M | NA | Soft palate | NA | Surg | NA | NED | 60 |
| 32 | Aydin et al(33), 2006 | 76 | F | 3.5×3.5×1.5 | Tonsil | FDC sarcoma | Surg + RT | NA | NED | 48 |
| 33 | Clement et al(30), 2006 | 27 | F | 4×3×2 | Tonsil | Nerve sheath tumor | Surg + RT | NA | NED | 6 |
| 34 | Shia et al(31), 2006 | 69 | F | NA | Tonsil | SCC | Surg + RT | DM (LN, lung), 96 | AWD | 108 |
| 35 | McDuffieet al(46), 2007 | 59 | F | 4 | Tonsil | FDC sarcoma | Surg + RT | NA | NED | 18 |
| 36 | Fan et al(32), 2007 | 48 | F | NA | Tonsil | Malignant lymphoma | Surg + RT + ChT | LR&DM (LN), 180 | AWD | 180 |
| 37 | Fan et al(32), 2007 | 42 | M | NA | Nasopharynx | FDC sarcoma | Surg + RT + ChT | DM (LN), 48 | AWD | 144 |
| 38 | Alexander et al(47), 2007 | 69 | M | 3 | Parapharyngeal space | Paraganglioma | Surg | LR, 12 | AWD | 12 |
| 39 | Soriano et al(17), 2007 | 33 | M | NA | Nasopharynx | NA | Surg + RT | LR, 10 | STD | 14 |
| 40 | Encabo et al(48), 2008 | 36 | F | 2.3×2.3 | Nasopharynx | Teratocarcinosarcoma | Surg + RT | NA | NED | 27 |
| 41 | Vaideeswar et al(49), 2009 | 50 | M | 2×2 | Tonsil | UD carcinoma | Surg | NA | NED | 48 |
| 42 | Duan et al(8), 2010 | 54 | F | 3×3×2 | Nasopharynx | UD-carcinoma | Surg + RT | NA | NED | 18 |
| 43 | Duan et al(8), 2010 | 41 | M | 3×3×2 | Nasopharynx | UD carcinoma | Surg | NA | NED | 7 |
| 44 | Duan et al(8), 2010 | 41 | M | 3×3×2 | Tonsil | FDC sarcoma | Surg | NA | NED | 9 |
| 45 | Duan et al(8), 2010 | 39 | F | 2×2×1 | Soft palate | Ectopic meningioma | Surg | NA | NED | 40 |
| 46 | Li et al(7), 2010 | 60 | M | 5 | Tonsil | Granuloma | Surg + RT | NA | NED | 86 |
| 47 | Li et al(7), 2010 | 35 | F | 5 | Parapharyngeal space | Nasopharyngeal sarcoma | Surg | LR, 2 | STD | 12 |
| 48 | Li et al(7), 2010 | 28 | F | 6 | Parapharyngeal space | FDC sarcoma | Surg + RT + ChT | DM (lung), 14 | AWD | 22 |
| 49 | Li et al(7), 2010 | 55 | M | 2 | Tonsil | FDC sarcoma | Surg + RT | LR, 18 | AWD | 21 |
| 50 | Young et al(50), 2010 | 65 | M | 3×2×1.7 | Tonsil | FDC sarcoma | Surg + RT | NA | NED | 24 |
| 51 | Suchitha et al(51), 2010 | 63 | M | 4.2×4×2 | Tonsil | FDC sarcoma | Surg + RT | NA | NED | 8 |
| 52 | Karabulut et al(37), 2012 | 70 | F | 3×3×2 | Nasopharynx | FDC sarcoma | Surg | LR, 12 | AWD | 46 |
F, female; M, male; CLN, cervical lymph nodes; ALN, axillary lymph nodes; surg, surgery; ChT, chemotherapy; RT, radiotherapy; AWD, alive with disease; NED, no evidence of disease; STD, succumbed to disease; NA, not available; LR, local recurrence; DM, distant metastasis; DFT, disease free time following surgery; LN, lymph node; FDC, follicular dendritic cell; NESCTWEF, nonepithelial spindle cell tumor with epithelial features; UD-carcinoma, undifferentiated carcinoma; SCC, squamous cell carcinoma.