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Activity dependence of unitary GPe–STN synaptic transmission. A, B, Example of unitary GPe–STN synaptic transmission during the first and 10th seconds of stimulation at 1 Hz (A) and 33 Hz (B). C, D, Population data (n = 5): mean reliability of transmission (C) and normalized conductance (D) at 1, 10, 20, 33, and 100 Hz stimulation. E, Steady-state reliability of transmission (●) and normalized conductance (▴) plotted against stimulation frequency.
