Figure 7.
GPe–STN synaptic depression is not the result of activation of presynaptic GABAB autoreceptors. A, B, Example of unitary GPe–STN synaptic transmission during the first and 10th seconds of stimulation at 33 Hz under control conditions (A) and in the presence of the GABAB receptor antagonist CGP 55845 (B; 2 μm). Inset, The entire stimulation period. C, Population data (n = 8): mean conductance (C1), mean normalized conductance (C2), and reliability of transmission (C3) against time and box plots illustrating amplitude of IPSC1 (C4) and ratio of IPSC2:IPSC1 (C5). Scale bars in B also apply to A. *p < 0.05.