Table 1. Calculated Combination Indexes for MK1775 and cytarabine in AML cell lines.

MK1775 and cytarabine are synergistic in inhibition of AML cellular proliferation.

MV4-11 or Molm13 cells were treated as in Figure 5A and the combination index (CI) was calculated for the various dose combinations. CI values less than one indicate synergistic inhibition of proliferation.

MV4-11
	ARA-C (nM)	MK1775 (nM)	Fa	CI
	600	20	0.700	0.601
	600	50	0.826	0.372
	600	100	0.975	0.089
	800	20	0.792	0.575
	800	50	0.963	0.155
	800	100	0.986	0.079
	1000	20	0.857	0.529
	1000	50	0.991	0.075
	1000	100	0.994	0.055
Molm13
	ARA-C (nM)	MK1775 (nM)	Fa	CI
	5	20	0.300	1.672
	5	50	0.509	1.17
	5	100	0.630	1.173
	10	20	0.625	1.32
	10	50	0.808	0.862
	10	100	0.889	0.761
	20	20	0.902	0.838
	20	50	0.971	0.427
	20	100	0.985	0.369
U937
	ARA-C (nM)	MK1775 (nM)	Fa	CI
	10	100	0.86	0.236
	10	200	0.76	0.572
	20	100	0.95	0.173
	20	200	0.38	1.223
	50	100	0.94	0.269
	50	200	0.71	0.845