Figure 1.

Overview of the MS signature creation process. We can see that the tumor MS signature contains a noticeably increased number of deviations from the straight line trajectory on account of the rays attempting to take the path of least resistance and, hence, overcome obstacles along the way. On the other hand, the MS signature for the non-tumor (stroma) region is much smoother as a result of comprising fewer and smaller objects. Note that a pre-defined stopping criterion is employed such that rays stop when they hit blank spaces