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Effect of mefloquine (MQ)-induced alteration of mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation in PCa cells. (A) DU145 and PC3 cells were treated with MQ (10 μM) for 60 min, and the change in MMP was analyzed by flow cytometry with DiOC6. (B) DU145 and PC3 cells were treated with the indicated concentration of MQ (10 μM) for 1 h, and the ROS level was determined using a 2′,7′-dichlorofluorescein-diacetate (DCFH-DA) dye.
