Table 2.

Efficacy: change from baseline to weeks 1, 2, and 4 in the total scores of Hamilton Rating Scale for depression and Montgomery– Åsberg Depression Rating Scale, and response and remission rates

	Mirtazapine		Duloxetine		P value for between-treatment group comparisons regarding change from baseline (MMRM)
	Mean ± SD (n)	P	mean ± SD (n)	P
% change HRSD
0–1 weeks (n)	31.8 ± 21.3 (22)	<0.0001	15.0 ± 21.7 (27)	0.0003	0.0401
0–2 weeks (n)	46.0 ± 20.5 (22)	<0.0001	27.5 ± 31.6 (27)	<0.0001	0.0181
0–4 weeks (n)	54.5 ± 29.5 (22)	<0.0001	31.4 ± 24.9 (27)	<0.0001	0.0421
% change MADRS
0–1 weeks (n)	32.8 ± 21.0 (22)	<0.0001	18.1 ± 24.7 (27)	0.0004	0.139
0–2 weeks (n)	42.1 ± 24.0 (22)	<0.0001	28.9 ± 30.0 (27)	<0.0001	0.119
0–4 weeks (n)	52.6 ± 26.8 (22)	<0.0001	33.7 ± 38.8 (27)	<0.0001	0.171
	Mirtazapine (n = 22)		Duloxetine (n = 28)		P
Response rate (%)	59.1		28.6		0.127
Remission rate (%)	31.8		10.7		0.152

Abbreviations: HRSD, Hamilton Rating Scale for Depression; MADRS, Montgomery–Åsberg Depression Rating Scale; MMRM, mixed-models repeated measures; SD, standard deviation.