Fig. 6.

Neurons are able to metabolically adapt following a brief OGD exposure. Lactate and pyruvate levels were measured at various times following an exposure to 5 or 90 min of OGD. The nonlethal 5 min OGD exposure did not significantly impact the production of lactate and pyruvate. In contrast, a lethal 90 min exposure results in a dramatic increase in lactate production and a loss of pyruvate over time indicating an inability for these neurons to adapt metabolically. Data were normalized to control cells and represent the mean from four-independent experiments ± SEM.