Fig.1. DDC-fed mice have limited tolerance for exercise and altered oxygen utilization.
Mice were challenged with acute maximal exercise on a treadmill. Time to exhaustion, (VO2), (VCO2) and (RER) were measured by indirect calorimetry as reported in Methods. DDC fed mice demonstrated early fatigue (A), lower VO2 (B) and high RER (D) when compared to chow fed mice at each time point. VCO2 did not did not differ between the groups. (*p<0.05; Results: Mean±SEM; n=6; Mann-Whitney for each time point). Note: Chow (□) and DDC (■)