Table 1. Bioinformatics-based prediction of NF-κB sites in eIFH promoters.
Gene Name | PutativeNF-κB site(s) byJASPAR | PutativeNF-κB site(s) byTFSEARCH | Position on promoter | NF-κB consensussequence | |
Core Initiation Factors | EIF1 | 0 | 0 | ||
EIF1A | 0 | 0 | |||
EIF2S1(eIF2-alpha) | 0 | 0 | |||
EIF2S2(eIF2-beta) | 1 | 0 | −684;−675 | CGGTGTTTCC | |
eIF2S3(eIF2-gamma) | 1 | 1 | −107; −98 | TGGAGTTTCC | |
eIF2B1 | 0 | 0 | |||
eIF2B2 | 0 | 0 | |||
eIF2B3 | 1 | 1 | −730; −721 | GGGACTTCCT | |
eIF2B4 | 0 | 0 | |||
EIF3A | 0 | 0 | |||
EIF3B | 0 | 0 | |||
EIF3E | 1 | 0 | −98; −89 | GGGGTTTACC | |
EIF3F | 0 | 0 | |||
EIF3G | 0 | 0 | |||
EIF3H | 0 | 0 | |||
EIF3I | 0 | 0 | |||
EIF3J | 0 | 0 | |||
EIF3K | 0 | 0 | |||
EIFS8 | 0 | 0 | |||
EIF4A1 | 1 | 1 | −418; −408 | GAGGATTCCCC | |
EIF4A2 | 2 | 2 | −362; −353−281; −272 | GGGGCTTCCC;CGGGGTTTCC | |
EIF4A3 | 0 | 0 | |||
EIF4B | 0 | 0 | |||
EIF4E | 0 | 0 | |||
EIF4G1 | 0 | 0 | |||
EIF4G2 | 1 | 0 | −671; −662 | CGGACATTCC | |
EIF4G3 | 0 | 0 | |||
EIF4H | 2 | 2 | −253; −244−210; −201 | GGGAGTTCCC;CGGCCTTTCC | |
EIF5 | 0 | 0 | |||
EIF5B | 1 | 0 | −238; −229 | CGGGTTTTCC |
Jaspar- and TFSEARCH-based computational analysis predicted putative NF-κB enhancers in the promoter regions of core eukaryotic translation initiation factors.