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. 2013 Jun 11;8(6):e65345. doi: 10.1371/journal.pone.0065345

Figure 1. The CLEC2L-encoded CTLR is highly conserved and a member of the CLEC2 subfamily of CTLR.

Figure 1

(A) Amino acid sequence alignment of the CTLDs of mouse Clec2l (mClec2l) and human CLEC2L (hCLEC2L) with NKC-encoded CLEC2 family members and other NKC-encoded CTLRs of human or mouse origin. Alignment starts with the first out of six highly conserved cysteines (Cys1 to Cys6) of the CTLD that are highlighted in black and numbered (bottom line) accordingly. The ‘WIGL’ motif of the hydrophobic core is indicated by asterisks (bottom line) and shaded, as are other conserved CTLD residues. Dots indicate sequence gaps. (B) Phylogenetic tree of the CTLD sequences shown in (A). Tree was generated with the PHYLIP program (http://evolution.genetics.washington.edu/phylip.html).