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. 2013 Jun 11;8(6):e66720. doi: 10.1371/journal.pone.0066720

Figure 2. Effects of vehicle and neuregulin treatment on heart morphology and function.

Figure 2

. A) Representative echocardiography loop images of non-treated (NT), vehicle-treated (Veh), and neuregulin-treated (Nrg) wildtype (+/+) and cMLCK knockout (−/−) hearts. B) Representative image of hematoxylin and eosin stain of fixed 4-chamber view of 3 month old male wildtype and cMLCK knockout, Veh and Nrg mouse hearts. Inset scale bar-2 mm. C, D, E) Percent fractional shortening (%FS), and left ventricular internal dimension at diastole (LVIDd) and systole (LVIDs). Sample number for each treatment group is indicated within each %FS bar. Non-treated shown in white, vehicle in gray, and neuregulin treatment in black. Significance was determined by 1-way ANOVA and Newman-Keuls multiple comparison test using GraphPad software. * P<0.05, ** P<0.01, *** P<0.001 compared with NT within its genotype group; # P<0.05, ## P<0.01, ### P<0.001 compared with treatment-matched wildtype group.