Table 2. Morphometric and echocardiographic parameters.
BW (g) | HW (mg) | TL (mm) | HW/TL | HW/BW | HR (bpm) | IVSd (mm) | PWd (mm) | |
+/+ NT | 24.8±1.1 | 116±5 | 18.0±0.1 | 6.48±0.23 | 4.69±0.08 | 694±13 | 0.77±0.05 | 0.70±0.04 |
+/+ Veh | 28.5±2.7 | 139±6 | 18.3±0.2 | 7.62±0.33 | 4.94±0.26 | 728±10 | 0.71±0.10 | 0.67±0.06 |
+/+ Nrg | 26.6±1.2 | 134±7 | 17.9±0.2 | 7.47±0.31 | 5.04±0.08 | 649±12 δ | 0.94±0.07 δ | 0.96±0.08 δ |
−/− NT | 24.3±0.8 | 128±3 | 17.9±0.1 | 7.13±0.14 | 5.27±0.12 # | 646±25 | 0.74±0.02 | 0.74±0.03 |
−/− Veh | 25.1±1.1 | 132±6 | 17.8±0.2 | 7.39±0.28 | 5.27±0.13 # | 690±23 | 0.80±0.07 | 0.83±0.07 |
−/− Nrg | 23.8±0.5 | 128±3 | 17.7±0.1 | 7.22±0.15 | 5.38±0.05 # | 691±15 | 0.85±0.04 δ | 0.99±0.04 δ |
N = 4 or more. Abbreviations are: BW, body weight; HW, heart weight; TL, tibial length; HR, heart rate; IVSd, interventricular septal wall diameter; PWd, posterior wall diameter. Significance determined using GraphPad software. #P<0.05 compared with non-treated wildtype (+/+ NT) hearts by 1 way ANOVA, Newman-Keuls multiple comparisons test; δP<0.05 compared with pre-treatment values (not shown) by paired t-test, parametric, one-tailed.