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. 2013 Jun 11;8(6):e65420. doi: 10.1371/journal.pone.0065420

Figure 3. Activities of GCG family peptides on GCRP receptor.

Figure 3

HEK293T cells were co-transfected with CRE-luc and plasmids containing chGCRPR (A), xeGCRPR (B), or mdGCRPR (C) in 48-well plates. Forty-eight hours after transfection, cells were treated with the indicated concentrations of peptides (▪ for GCRP; • for chGIP; ◊ for chGLP2; ○ for chGCG; △ for huGLP1; ▾ for Exe-4). Species-specific responses of chGCRPR (D), xeGCRPR (E), and mdGCRPR (F) were determined by treating cells with increasing concentrations of GCRP (▾ for chGCRP; ? for xeGCRP; • for mdGCRP) for 6 h, and luciferase activity was examined.