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. 2013 Jun 11;8(6):e65420. doi: 10.1371/journal.pone.0065420

Figure 6. GCRPR-mediated signaling pathway.

Figure 6

cAMP accumulation (A) or IP production (B) in response to various concentrations of GCRP was determined in HEK293T cells transfected with plasmids containing GCRP receptors (• for chGCRPR; ▾ for xeGCRPR; ◊ for mdGCRPR). mdGCRP induces SRE-luc activity through mdGCRPR (C). Forty-eight hours after transfection with the receptor and the reporter genes, HEK293T cells were treated with different concentrations of GCRPs for 6 h. Luciferase activity was determined.