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. 2013 Jun 11;8(6):e65420. doi: 10.1371/journal.pone.0065420

Table 5. Ligand potency (EC₅₀ value) and efficacy (E_max value) for GCRPR, GLP1R, and chimeric receptors.

	chGCRPR		chGLP1R		chimeric chGCRPR/chGLP1R		chimeric chGCRPR/huGLP1R
peptides	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max	EC₅₀	E_max
	[nM]	[foldinduction]	[nM]	[foldinduction]	[nM]	[foldinduction]	[nM]	[foldinduction]
chGCRP	0.32±0.06	5.56±0.09	8.03±0.60	19.16±0.19	8.57±0.87	7.30±0.09	9.44±1.31	62.88±1.27
chGLP1	18.28±1.76^a	5.80±0.07	0.20±0.03^a	28.23±0.39^a	1.52±0.13^a	12.64±0.13^a	2.29±0.44^a	91.94±2.18^a
[GQA]GCRP	0.28±0.05^b	5.60±0.09	0.94±0.13^a	18.99±0.30^b	0.63±0.06^a	7.18±0.07^b	0.86±0.14^a	60.62±1.15^b
[KMK]GLP1	1.02±0.19^b	5.77±0.10	0.50±0.06^a	28.38±0.39^a	1.71±0.14^a	12.77±0.12^a	3.25±0.48^a	91.15±1.65^a

Results are presented as mean ± S.E. of at least three independent experiments. a, P<0.05 vs. chGCRP; b, P<0.05 vs. chGLP1.