Table 2. Genotype and allele frequencies of the SEPS1 G-105A polymorphism in preterm neonates and controls.
| Cases (%) | Controls (%) | Crude | Adjusted | |||
| (n = 569) | (n = 673) | OR (95% CI) | P value | OR (95% CI) | P value | |
| Genotypes | ||||||
| GG | 458 (80.9) | 597 (88.7) | Reference | Reference | ||
| GA | 99 (17.5) | 75 (11.1) | ||||
| AA | 9 (1.6) | 1 (0.2) | ||||
| GA + AA | 108 (19.1) | 76 (11.3) | 1.85 (1.35–2.55)a | <0.001a | 1.87 (1.36–2.57)c | <0.001c |
| Alleles | ||||||
| G allele | 0.90 | 0.94 | <0.001b | |||
| A allele | 0.10 | 0.06 | ||||
NOTE: Due to genotyping failure, the actual sample size, respectively, was 566 and 673 for cases and controls.
Abbreviations: OR, odds ratio; CI, confidence interval.
a
ORs and P values obtained against reference by χ 2 test (2×2).
b
Two-sided χ2 test for distribution of allelic frequencies (df = 1).
c
ORs and P values were calculated by multivariate logistic regression, adjusted for maternal age at delivery (year) and neonatal sex.