Table 5. Genotype and allele frequencies of the SEPS1 G-105A polymorphism in controls and three sub-categories of SPTB neonates.
| Cases (%) | Controls (%) (n = 673) | OR (95% CI) | P value | |||||||
| P1 (n = 26) | P2 (n = 97) | P3 (n = 446) | P1 vs. Controls | P2 vs. Controls | P3 vs. Controls | P1 vs. Controls | P2 vs. Controls | P3 vs. Controls | ||
| Genotypes | ||||||||||
| GG | 16 (64.0) | 79 (81.4) | 363 (81.8) | 597 (88.7) | Reference | Reference | Reference | Reference | Reference | Reference |
| GA | 9 (36.0) | 18 (18.6) | 72 (16.2) | 75 (11.1) | ||||||
| AA | 0 | 0 | 9 (2.0) | 1 (0.2) | ||||||
| GA + AA | 9 (36.0) | 18 (18.6) | 81 (18.2) | 76 (11.3) | ||||||
| GG vs. GA + AA | 4.42 (1.89–10.35)a | 1.79 (1.02–3.15)a | 1.75 (1.25–2.46)a | 0.002a | 0.053a | 0.001a | ||||
| GG vs. GA + AA | 4.46 (1.86–10.73)b | 1.81 (1.03–3.19)b | 1.76 (1.25–2.47) b | 0.002b | 0.050b | 0.001b | ||||
| Alleles | ||||||||||
| G allele | 0.82 | 0.91 | 0.90 | 0.94 | <0.001c | 0.054c | <0.001c | |||
| A allele | 0.18 | 0.09 | 0.10 | 0.06 | ||||||
NOTE: Due to genotyping failure, the actual sample size, respectively, was 566 and 673 for cases and controls. P1, extremely preterm neonates; P2, very preterm neonates; P3, moderately preterm neonates.
Abbreviations: OR, odds ratio; CI, confidence interval.
a
ORs and P values obtained against reference by χ 2 test (2×2).
b
ORs and P values were calculated by multivariate logistic regression, adjusted for maternal age at delivery (year) and neonatal sex.
c
Two-sided χ2 test for distribution of allelic frequencies (df = 1).