Table 1.
Spinal motor neuron gem counts
| Group ID | Genotype | Avg. gems per cell | MNs counted | MNs with gems | % MNs with gems | Number of cells with |
N | |||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 Gems | 1 Gem | 2 Gems | 3 Gems | |||||||
| Control | SMN2+/−, Smn2B-Neo/+ | 1.07 ± 0.19 | 155 | 106 | 68 ± 5% | 49 | 61 | 29 | 16 | 3 |
| SMA | SMN2+/−, Smn2B-Neo/2B-Neo | 0.19 ± 0.02** | 149 | 26 | 17 ± 3% | 123 | 24 | 2 | 0 | 3 |
| Motor Neuron Rescue SMA | SMN2+/−, Smn2B-Neo/2B-Neo, Hb9-Cre+/− | 0.63 ± 0.11† | 250 | 122 | 51 ± 2% | 128 | 99 | 13 | 10 | 5 |
Table values are mean ± SEM **p ≤ 0.01 relative to control;
†p ≤ 0.05 relative to severe inducible SMA. N = number of biological replicates. One-way ANOVA with Bonferroni's post hoc analysis.