TABLE 3.
Association of Objective Socioeconomic Status Measures with Inflammatory Biomarkers in Multivariable Regression Models and Sobel Testing for Mediation by BMI z score
| IL-6 | sTNFR2 | Fibrinogen | ||||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | β (95% CI) | β (95% CI) | ||||||
| SES | SES + BMIz | SES | SES + BMIz | SES | SES + BMIz | |||
| Parent Educationa | ||||||||
| ≤ High School |
.112 (.044, .181) |
.089 (.023, .155) |
.031 (.008, .053) |
.025 (.003, .047) |
.017 (.0008, .033) |
.009 (−.007, .024) |
||
| Some College |
.096 (.032, .160) |
.063 (.0004, .126) |
.022 (.0008, .043) |
.014 (−.007, .035) |
.016 (.001, .032) |
.006 (−.009, .020) |
||
| College Graduate | .017 (−.045, .078) |
.007 (−.052, .067) |
.0009 (−.018, .020) |
−.001 (−.021, .018) |
.008 (−.007, .024) |
.004 (−.010, .019) |
||
| Overall P | <.001 | .01 | .01 | .07 | .13 | .74 | ||
| BMIz |
.080 (.057, .102) |
.018 (.010, .026) |
.027 (.021, .032) |
|||||
| Sobel testing |
Z statistic |
P |
Z statistic |
P | ||||
| 3.41 | <.001 | 2.98 | .003 | |||||
| Household Income ($10,000) | −.005 (−.010, .0002) |
−.003 (−.008, .002) |
−.001 (−.003, .0005) |
−.0008 (−.003, .0009) |
−.0005 (−.002, .0008) |
−.0001 (−.001, .001) |
||
IL-6 = interleukin-6; sTNFR2 = soluble tumor necrosis factor receptor 2; CI = confidence interval; SES = socioeconomic status; BMIz = body mass index z-score
a
Reference category is professional degree.
NOTE: Biomarkers are log-transformed. Models adjust for age, race, gender, and pubertal status. Income models also adjust for number of people in the household.