Table 1.
Dopamine D2 receptor occupancy by ziprasidone (n=11 for each scan)
| 5 hours post- dose scan | 13 hours post- dose scan | 23 hours post- dose scan | Differences across time-points (Wilcoxon signed rank test) | ||
|---|---|---|---|---|---|
| Putamen | Mean ± SD (%) | 65.6 ± 9.9 | 38.5 ± 25.8 | 1.99 ± 30.2 | 5h vs 13h: Z = −2.191, p = 0.028; 13h vs 23h: Z = −2.701, p = 0.007 |
| Median (%) | 67.0 | 31.0 | −9.97 | ||
| Range (%) | 9.4–78.6 | −4.41–76.8 | −37.6 −66.2 | ||
| Caudate | Mean ± SD (%) | 62.4 ± 10.0 | 34.9 ± 24.6 | −5.72 ± 31.3 | 5h vs 13h: Z = −2.497, p = 0.013; 13h vs 23h: Z = −2.701, p = 0.007 |
| Median (%) | 64.5 | 30.7 | −14.0 | ||
| Range (%) | 41.9 −77.9 | −0.449 −75.8 | −61.4–49.2 % | ||
| Ventral striatum | Mean ± SD (%) | 68.1 ± 7.7 | 46.8 ± 20.9 | 11.2 ± 29.8– | 5h vs 13h: Z = −2.497, p = 0.013; 13h vs 23h: Z = −2.497, p = 0.013 |
| Median (%) | 69.7 | 43.0 | 2.50 | ||
| Range (%) | 56.0–80.1 | 11.0–79.4 | −26.9–61.5 |